Comparison of cardiac image-derived input functions for quantitative whole body [¹⁸F]FDG imaging with arterial blood sampling.

ABSTRACT: Introduction: Dynamic positron emission tomography (PET) and the application of kinetic models can provide important quantitative information based on its temporal information. This however requires arterial blood sampling, which can be challenging to acquire. Nowadays, state-of-the-art PET/CT systems offer fully automated, whole-body (WB) kinetic modelling protocols using image-derived input functions (IDIF) to replace arterial blood sampling. Here, we compared the validity of an automatic WB kinetic model protocol to the reference standard arterial input function (AIF) for both clinical and research settings. Methods: Sixteen healthy participants underwent dynamic WB [¹⁸F]FDG scans using a continuous bed motion PET/CT system with simultaneous arterial blood sampl

SUBMITTER: Reed MB 

PROVIDER: S-EPMC10073457 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature