Therapeutic potential of bone marrow mesenchymal stem cells in cyclophosphamide-induced infertility.

ABSTRACT: Cancer is a deadly disease characterized by abnormal cell proliferation. Chemotherapy is one technique of cancer treatment. Cyclophosphamide (CYP) is the most powerful chemotherapy medication, yet it has serious adverse effects. It is an antimitotic medicine that regulates cell proliferation and primarily targets quickly dividing cells, and it has been related to varying levels of infertility in humans. In the current study, we assessed the biochemical, histological, and microscopic evaluations of testicular damage following cyclophosphamide administration. Further, we have explored the potential protective impact of mesenchymal stem cell (MSCs) transplantation. The biochemical results revealed that administration of cyclophosphamide increased serum concentrations of follicle-stimulating h

SUBMITTER: Ibrahim D 

PROVIDER: S-EPMC10073512 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature