Rapid induction onto extended-release injectable buprenorphine following opioid overdose: A case series.

ABSTRACT:

Background

Buprenorphine treatment has been associated with reduced non-prescribed opioid use and opioid related overdose (OD). We evaluated initial outcomes of rapid induction onto extended-release injectable buprenorphine (BUP-XR) within 7 days of emergency department presentation for unintentional OD.

Methods

Between February 2019-February 2021, N = 19 patients with opioid use disorder received buprenorphine/naloxone (4/1 mg), followed by BUP-XR (300 mg) at induction and continued BUP-XR outpatient for 6 months. Primary outcomes included adverse events, repeat OD, and death.

Results

For patients who received at least one dose of BUP-XR, there were no treatment related serious adverse events or symptoms of precipitated withdrawal. In addition, there were no r

SUBMITTER: Ochalek TA 

PROVIDER: S-EPMC10073633 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature