Evolutionary and in silico guided development of novel peptide analogues for antibacterial activity against ESKAPE pathogens.

ABSTRACT: According to WHO, to combat the resistant strains, new effective anti-microbial agents are needed on an urgent basis and global researchers should focus their efforts and discovery programs on developing them against antibiotic-resistant pathogens or priority pathogens like ESKAPE. In this context, Cationic antimicrobial peptides (AMPs) are being explored extensively as promising next-generation antimicrobials due to their broad range, fast kinetics and multifunctional role. Despite recent advances, it is still a daunting challenge to identify and design a potent AMP with no cytotoxicity, but with broad specific antimicrobial activity, stability and efficacy under in vivo conditions in a cost-effective and robust manner. In this work, as a proof of concept, we designed novel potent

SUBMITTER: Lata M 

PROVIDER: S-EPMC10073642 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature