Selenium speciation-dependent cancer radiosensitization by induction of G2/M cell cycle arrest and apoptosis.

ABSTRACT: Introduction: Radiation therapy has Q6long been a routine and effective treatment for non-small cell lung cancer (NSCLC), but the radioresistance and side effects have limited its application. In recent years, the superiority showed by trace element selenium in tumor radiotherapy sensitization has received wide attention. However, different forms of selenium compounds exhibit different chemical properties and their mechanisms of action on tumors may be different. Methods: Human non-small cell lung cancer SPC-A1 cells were studied. Drug toxicity was detected by MTT assay. The selenium content absorbed in vitro at different time points was detected by ICP-MS. Colony formation were conducted to observe the radiosensitization effect of different selenium compounds on SPC-A1 cells

SUBMITTER: Nie S 

PROVIDER: S-EPMC10073679 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature