A subfamily classification to choreograph the diverse activities within glycoside hydrolase family 31.

ABSTRACT: The Carbohydrate-Active Enzyme classification groups enzymes that breakdown, assemble, or decorate glycans into protein families based on sequence similarity. The glycoside hydrolases (GH) are arranged into over 170 enzyme families, with some being very large and exhibiting distinct activities/specificities towards diverse substrates. Family GH31 is a large family that contains more than 20,000 sequences with a wide taxonomic diversity. Less than 1% of GH31 members are biochemically characterized and exhibit many different activities that include glycosidases, lyases, and transglycosidases. This diversity of activities limits our ability to predict the activities and roles of GH31 family members in their host organism and our ability to exploit these enzymes for practical purposes. Here, w

SUBMITTER: Arumapperuma T 

PROVIDER: S-EPMC10074150 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature