Dataset Information

Impact of days elapsed from the onset of symptoms to hospitalization in COVID-19 in-hospital mortality: time matters.

ABSTRACT:

Background

COVID-19 shows different clinical and pathophysiological stages over time. The effect of days elapsed from the onset of symptoms (DEOS) to hospitalization on COVID-19 prognostic factors remains uncertain. We analyzed the impact on mortality of DEOS to hospitalization and how other independent prognostic factors perform when taking this time elapsed into account.

Methods

This retrospective, nationwide cohort study, included patients with confirmed COVID-19 from February 20th and May 6th, 2020. The data was collected in a standardized online data capture registry. Univariate and multivariate COX-regression were performed in the general cohort and the final multivariate model was subjected to a sensitivity analysis in an early presenting (EP; <5 DEOS) and late presenting (LP; ≥5 DEOS) group.

Results

7915 COVID-19 patients were included in the analysis, 2324 in the EP and 5591 in the LP group. DEOS to hospitalization was an independent prognostic factor of in-hospital mortality in the multivariate Cox regression model along with other 9 variables. Each DEOS increment accounted for a 4.3% mortality risk reduction (HR 0.957; 95% CI 0.93-0.98). Regarding variations in other mortality predictors in the sensitivity analysis, the Charlson Comorbidity Index only remained significant in the EP group while D-dimer only remained significant in the LP group.

Conclusion

When caring for COVID-19 patients, DEOS to hospitalization should be considered as their need for early hospitalization confers a higher risk of mortality. Different prognostic factors vary over time and should be studied within a fixed timeframe of the disease.

SUBMITTER: Maestro de la Calle G

PROVIDER: S-EPMC10074179 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature

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Publications

Impact of days elapsed from the onset of symptoms to hospitalization in COVID-19 in-hospital mortality: time matters.

Maestro de la Calle G G García Reyne A A Lora-Tamayo J J Muiño Miguez A A Arnalich-Fernandez F F Beato Pérez J L JL Vargas Núñez J A JA Caudevilla Martínez M A MA Alcalá Rivera N N Orviz Garcia E E Sánchez Moreno B B Freire Castro S J SJ Rhyman N N Pesqueira Fontan P M PM Piles L L López Caleya J F JF Fraile Villarejo M E ME Jiménez-García N N Boixeda R R González Noya A A Gracia Gutiérrez A A Martín Oterino J Á JÁ Gómez Huelgas R R Antón Santos J M JM Lumbreras Bermejo C C

Revista clinica espanola 20230328 5

<h4>Background</h4>COVID-19 shows different clinical and pathophysiological stages over time. The effect of days elapsed from the onset of symptoms (DEOS) to hospitalization on COVID-19 prognostic factors remains uncertain. We analyzed the impact on mortality of DEOS to hospitalization and how other independent prognostic factors perform when taking this time elapsed into account.<h4>Methods</h4>This retrospective, nationwide cohort study, included patients with confirmed COVID-19 from February ...[more]

PMID: 36997085

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Dataset Information

Impact of days elapsed from the onset of symptoms to hospitalization in COVID-19 in-hospital mortality: time matters.

Background

Methods

Results

Conclusion

Publications

Impact of days elapsed from the onset of symptoms to hospitalization in COVID-19 in-hospital mortality: time matters.

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