Nucleotide metabolism is linked to cysteine availability.

ABSTRACT: The small molecule erastin inhibits the cystine-glutamate antiporter, system x_c^-, which leads to intracellular cysteine and glutathione depletion. This can cause ferroptosis, which is an oxidative cell death process characterized by uncontrolled lipid peroxidation. Erastin and other ferroptosis inducers have been shown to affect metabolism but the metabolic effects of these drugs have not been systematically studied. To this end, we investigated how erastin impacts global metabolism in cultured cells and compared this metabolic profile to that caused by the ferroptosis inducer RAS-selective lethal 3 or in vivo cysteine deprivation. Common among the metabolic profiles were alterations in nucleotide and central carbon metabolism. Supplementing nucleosides to cysteine-de

SUBMITTER: Allen AE 

PROVIDER: S-EPMC10074211 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature