Novel Metabolic Subtypes in Pregnant Women and Risk of Early Childhood Obesity in Offspring.

ABSTRACT:

Importance

The in utero metabolic milieu is associated with offspring adiposity. Standard definitions of maternal obesity (according to prepregnancy body mass index [BMI]) and gestational diabetes (GDM) may not be adequate to capture subtle yet important differences in the intrauterine environment that could be involved in programming.

Objectives

To identify maternal metabolic subgroups during pregnancy and to examine associations of subgroup classification with adiposity traits in their children.

Design, setting, and participants

This cohort study included mother-offspring pairs in the Healthy Start prebirth cohort (enrollment: 2010-2014) recruited from University of Colorado Hospital obstetrics clinics in Aurora, Colorado. Follow-up of women and children is ongoing.

SUBMITTER: Francis EC 

PROVIDER: S-EPMC10074224 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature