Limited induction of polyfunctional lung-resident memory T cells against SARS-CoV-2 by mRNA vaccination compared to infection.

ABSTRACT: Resident memory T cells (T_RM) present at the respiratory tract may be essential to enhance early SARS-CoV-2 viral clearance, thus limiting viral infection and disease. While long-term antigen-specific T_RM are detectable beyond 11 months in the lung of convalescent COVID-19 patients, it is unknown if mRNA vaccination encoding for the SARS-CoV-2 S-protein can induce this frontline protection. Here we show that the frequency of CD4⁺ T cells secreting IFNγ in response to S-peptides is variable but overall similar in the lung of mRNA-vaccinated patients compared to convalescent-infected patients. However, in vaccinated patients, lung responses present less frequently a T_RM phenotype compared to convalescent infected individuals and polyfunctional CD10

SUBMITTER: Pieren DKJ 

PROVIDER: S-EPMC10074357 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature