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Oxime@Zirconium-Metal-Organic Framework Hybrid Material as a Potential Antidote for Organophosphate Poisoning.

ABSTRACT: A novel material with dual activity toward organophosphate (OP) poisoning, based on Zr-MOF-808 and neutral oxime RS69N, has been prepared. The hybrid material has a significant drug payload (5.2 ± 0.9 oxime to MOF-808 molar ratio) and shows a sustained oxime release in simulated physiological media, leading to the successful reactivation of OP-inhibited acetylcholinesterase. At the same time, the hybrid system presents an efficient and moderately fast removal rate of a toxic organophosphorus model compound (diisopropylfluorophosphate) from simulated physiological media (t_1/2 = 183 min; 95% removal rate after 24 h).

SUBMITTER: Gonzalez L

PROVIDER: S-EPMC10074384 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature

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Oxime@Zirconium-Metal-Organic Framework Hybrid Material as a Potential Antidote for Organophosphate Poisoning.

González Lydia L Martín-Romera Javier D JD Sánchez-Sánchez Purificación P Navarro Jorge A R JAR Barea Elisa E Maldonado Carmen R CR Carmona Francisco J FJ

Inorganic chemistry 20230320 13

A novel material with dual activity toward organophosphate (OP) poisoning, based on Zr-MOF-808 and neutral oxime RS69N, has been prepared. The hybrid material has a significant drug payload (5.2 ± 0.9 oxime to MOF-808 molar ratio) and shows a sustained oxime release in simulated physiological media, leading to the successful reactivation of OP-inhibited acetylcholinesterase. At the same time, the hybrid system presents an efficient and moderately fast removal rate of a toxic organophosphorus mod ...[more]

PMID: 36939843

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