Probing Unexpected Reactivity in Radiometal Chemistry: Indium-111-Mediated Hydrolysis of Hybrid Cyclen-Hydroxypyridinone Ligands.

ABSTRACT: Chelators based on hydroxypyridinones have utility in incorporating radioactive metal ions into diagnostic and therapeutic agents used in nuclear medicine. Over the course of our hydroxypyridinone studies, we have prepared two novel chelators, consisting of a cyclen (1,4,7,10-tetraazacyclododecane) ring bearing two pendant hydroxypyridinone groups, appended via methylene acetamide motifs at either the 1,4-positions (L¹) or 1,7-positions (L²) of the cyclen ring. In radiolabeling reactions of L¹ or L² with the γ-emitting radioisotope, [¹¹¹In]In³⁺, we have observed radiometal-mediated hydrolysis of a single amide group of either L¹ or L

SUBMITTER: Rivas C 

PROVIDER: S-EPMC10074387 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature