Fine-tuning the sequential drug release of nano-formulated mutual prodrugs dictates the combination effects.

ABSTRACT: The maintenance of robust ratiometric loading of dual therapeutic agents and fine-tuning release kinetics for consistent in vitro and in vivo optimization of combination effects is vital for discovering new anticancer drug combinations and remains challenging. Smart nanomedicine strategies have been investigated for this purpose, but most of the reported strategies focus either on ratiometric delivery or on unimodal sequential release of the two different agents, which hampers effective optimization of combination effects. Herein we report a sequential drug release system based on nanoformulated mutual prodrugs constructed by the formation of ketal linkages with different acid sensitivities, thus enabling the acid-triggered release of two anticancer drugs, paclitaxel and gemc

SUBMITTER: Zhong H 

PROVIDER: S-EPMC10074403 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature