PyrroTriPol: a semi-rigid trityl-nitroxide for high field dynamic nuclear polarization.

ABSTRACT: Magic angle spinning (MAS) dynamic nuclear polarization (DNP) has significantly broadened the scope of solid-state NMR to study biomolecular systems and materials. In recent years, the advent of very high field DNP combined with fast MAS has brought new challenges in the design of polarizing agents (PA) used to enhance nuclear spin polarization. Here, we present a trityl-nitroxide PA family based on a piperazine linker, named PyrroTriPol, for both aqueous and organic solutions. These new radicals have similar properties to that of TEMTriPol-I and can be readily synthesized, and purified in large quantities thereby ensuring widespread application. The family relies on a rigid bridge connecting the trityl and the nitroxide offering a better control of the electron spin-spin interactions thus

SUBMITTER: Halbritter T 

PROVIDER: S-EPMC10074417 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature