Advanced Brain Age and Chronic Poststroke Aphasia Severity.

ABSTRACT:

Background and objectives

Chronic poststroke language impairment is typically worse in older individuals or those with large stroke lesions. However, there is unexplained variance that likely depends on intact tissue beyond the lesion. Brain age is an emerging concept, which is partially independent from chronologic age. Advanced brain age is associated with cognitive decline in healthy older adults; therefore, we aimed to investigate the relationship with stroke aphasia. We hypothesized that advanced brain age is a significant factor associated with chronic poststroke language impairments, above and beyond chronologic age, and lesion characteristics.

Methods

This cohort study retrospectively evaluated participants from the Predicting Outcomes of Language Rehabilitation in A

SUBMITTER: Busby N 

PROVIDER: S-EPMC10074460 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature