Vitamin D improves hepatic steatosis in NAFLD via regulation of fatty acid uptake and β-oxidation.

ABSTRACT:

Introduction

The study aimed to explore the association of serum 25(OH)D₃ and hepatic steatosis in non-alcoholic fatty liver disease (NAFLD) patients and to determine whether the effect of vitamin D (VD) is mediated by activation of the peroxisome proliferator-activated receptor α (PPARα) pathway.

Methods

The study contained a case-control study, in vivo and in vitro experiments. A case-control study was conducted to compare serum parameters between NAFLD patients and controls and to evaluate the association of 25(OH)D₃ and NAFLD. In vivo study, male Wistar rats were randomly divided into control and model groups, fed a standard chow diet and a high-fat diet (HFD), respectively, for 7 weeks to generate an NAFLD model. Then, the rats

SUBMITTER: Du T 

PROVIDER: S-EPMC10074590 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature