Prediction of hot spots in protein-DNA binding interfaces based on discrete wavelet transform and wavelet packet transform.

ABSTRACT:

Background

Identification of hot spots in protein-DNA binding interfaces is extremely important for understanding the underlying mechanisms of protein-DNA interactions and drug design. Since experimental methods for identifying hot spots are time-consuming and expensive, and most of the existing computational methods are based on traditional protein-DNA features to predict hot spots, unable to make full use of the effective information in the features.

Results

In this work, a method named WTL-PDH is proposed for hot spots prediction. To deal with the unbalanced dataset, we used the Synthetic Minority Over-sampling Technique to generate minority class samples to achieve the balance of dataset. First, we extracted the solvent accessible surface area features and structural fea

SUBMITTER: Sun Y 

PROVIDER: S-EPMC10074722 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature