Dataset Information

Molecular epidemiology analysis of symptomatic and asymptomatic norovirus infections in Chinese infants.

ABSTRACT:

Background

Norovirus is a leading cause of acute gastroenteritis among children. Previous studies based on symptomatic infections indicated that mutations, rather than recombination drove the evolution of the norovirus ORF2. These characteristics were found in hospital-based symptomatic infections, whereas, asymptomatic infections are frequent and contribute significantly to transmission.

Methods

We conducted the first norovirus molecular epidemiology analysis covering both symptomatic and asymptomatic infections derived from a birth cohort study in the northern China.

Results

During the study, 14 symptomatic and 20 asymptomatic norovirus infections were detected in 32 infants. Out of the 14 strains that caused symptomatic infections, 12 strains were identified as GII.3[P12], and others were GII.4[P31]. Conversely, 17 asymptomatic infections were caused by GII.4[P31], two by GII.2[P16], and one by GII.4[P16]. Regardless of symptomatic and asymptomatic infections, the mutations were detected frequently in the ORF2 region, and almost all recombination were identified in the RdRp-ORF2 region. The majority of the mutations were located around the predefined epitope regions of P2 subdomain indicating a potential for immune evasion.

Conclusion

The role of symptomatic as well as asymptomatic infections in the evolution of norovirus needs to be evaluated continuously.

SUBMITTER: Chen LN

PROVIDER: S-EPMC10074819 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature

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Publications

Molecular epidemiology analysis of symptomatic and asymptomatic norovirus infections in Chinese infants.

Chen Li-Na LN Wang Si-Jie SJ Wang Song-Mei SM Fu Xiao-Li XL Zheng Wen-Jing WJ Hao Zhi-Yong ZY Zhou Hai-Song HS Zhang Xin-Jiang XJ Zhao Yu-Liang YL Qiu Chao C von Seidlein Lorenz L Qiu Tian-Yi TY Wang Xuan-Yi XY

Virology journal 20230404 1

<h4>Background</h4>Norovirus is a leading cause of acute gastroenteritis among children. Previous studies based on symptomatic infections indicated that mutations, rather than recombination drove the evolution of the norovirus ORF2. These characteristics were found in hospital-based symptomatic infections, whereas, asymptomatic infections are frequent and contribute significantly to transmission.<h4>Methods</h4>We conducted the first norovirus molecular epidemiology analysis covering both sympto ...[more]

PMID: 37016444

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Project description:BackgroundThe huge surge in COVID-19 cases in Karnataka state, India, during early phase of the pandemic especially following return of residents from other states and countries required investigation with respect to transmission dynamics, clinical status, demographics, comorbidities and mortality. Knowledge on the role of symptomatic and asymptomatic cases in transmission of SARS-CoV-2 was not available.MethodsThe study included all the cases reported from March 8 - May 31, 2020. Individuals with a history of international or domestic travel from high burden states, Influenza-like Illness or Severe Acute Respiratory Illness and high-risk contacts of COVID-19 cases were included. Detailed analysis based on contact tracing data available from the line-list of state surveillance unit was performed using cluster network analysis software.FindingsAmongst the 3404 COVID-19 positive cases, 3096 (91%) were asymptomatic while 308 (9%) were symptomatic. Majority of asymptomatic cases were in the age range of 16 and 45 years while symptomatic cases were between 31 and 65 years. Mortality rate was especially higher among middle-aged and elderly cases with co-morbidities, 34/38 (89·4%). Cluster network analysis of 822 cases indicated that the secondary attack rate, size of the cluster and superspreading events were higher when the source case was symptomatic as compared to an asymptomatic.InterpretationOur findings indicate that both asymptomatic and symptomatic SARS-CoV-2 cases transmit the infection, although symptomatic cases were the main driving force within the state during the beginning of the pandemic. Considering the large proportion of asymptomatic cases, their ability to spread infection cannot be overlooked. Notwithstanding the limitations and bias in identifying asymptomatic cases, the findings have major implications for testing policies. Active search, early testing and treatment of symptomatic elderly patients with comorbidities should be prioritized for containing the spread of COVID-19 and reducing mortality.FundingIntermediate Fellowship, Wellcome Trust-DBT India Alliance to Giridhara R Babu, Grant number: IA/CPHI/14/1/501499.

Dataset Information

Molecular epidemiology analysis of symptomatic and asymptomatic norovirus infections in Chinese infants.

Background

Methods

Results

Conclusion

Publications

Molecular epidemiology analysis of symptomatic and asymptomatic norovirus infections in Chinese infants.

Similar Datasets

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