Molecular epidemiology analysis of symptomatic and asymptomatic norovirus infections in Chinese infants.

ABSTRACT:

Background

Norovirus is a leading cause of acute gastroenteritis among children. Previous studies based on symptomatic infections indicated that mutations, rather than recombination drove the evolution of the norovirus ORF2. These characteristics were found in hospital-based symptomatic infections, whereas, asymptomatic infections are frequent and contribute significantly to transmission.

Methods

We conducted the first norovirus molecular epidemiology analysis covering both symptomatic and asymptomatic infections derived from a birth cohort study in the northern China.

Results

During the study, 14 symptomatic and 20 asymptomatic norovirus infections were detected in 32 infants. Out of the 14 strains that caused symptomatic infections, 12 strains were identified as GII

SUBMITTER: Chen LN 

PROVIDER: S-EPMC10074819 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature