Polymorphism of genes encoding drug-metabolizing and inflammation-related enzymes for susceptibility to cholangiocarcinoma in Thailand.

ABSTRACT:

Background

Cholangiocarcinoma (CCA) is an intractable cancer, and its incidence in northeastern Thailand is the highest worldwide. Infection with the liver fluke Opisthorchis viverrini (OV) has been associated with CCA risk. However, animal experiments have suggested that OV alone does not induce CCA, but its combination with a chemical carcinogen like nitrosamine can cause experimentally induced CCA in hamsters. Therefore, in humans, other environmental and genetic factors may also be involved.

Aim

To examine relations between risk for CCA and genetic polymorphisms in carcinogen-metabolizing and inflammation-related genes.

Methods

This hospital-based case-control study enrolled 95 case-control pairs matched by age (± 5 years) and sex. We examined relations bet

SUBMITTER: You G 

PROVIDER: S-EPMC10074948 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature