L- and T-type Ca²⁺ channels dichotomously contribute to retinal ganglion cell injury in experimental glaucoma.

ABSTRACT: Retinal ganglion cell apoptotic death is the main pathological characteristic of glaucoma, which is the leading cause of irreversible blindness. Disruption of Ca²⁺ homeostasis plays an important role in glaucoma. Voltage-gated Ca²⁺ channel blockers have been shown to improve vision in patients with glaucoma. However, whether and how voltage-gated Ca²⁺ channels are involved in retinal ganglion cell apoptotic death are largely unknown. In this study, we found that total Ca²⁺ current densities in retinal ganglion cells were reduced in a rat model of chronic ocular hypertension experimental glaucoma, as determined by whole-cell patch-clamp electrophysiological recordings. Further analysis showed that L-type Ca²⁺ currents were downregulated

SUBMITTER: Wang HN 

PROVIDER: S-EPMC10075096 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature