Serine and arginine rich splicing factor 1: a potential target for neuroprotection and other diseases.

ABSTRACT: Alternative splicing is the process of producing variably spliced mRNAs by choosing distinct combinations of splice sites within a messenger RNA precursor. This splicing enables mRNA from a single gene to synthesize different proteins, which have different cellular properties and functions and yet arise from the same single gene. A family of splicing factors, Serine-arginine rich proteins, are needed to initiate the assembly and activation of the spliceosome. Serine and arginine rich splicing factor 1, part of the arginine/serine-rich splicing factor protein family, can either activate or inhibit the splicing of mRNAs, depending on the phosphorylation status of the protein and its interaction partners. Considering that serine and arginine rich splicing factor 1 is either an activator or an

SUBMITTER: Sandoval-Castellanos AM 

PROVIDER: S-EPMC10075106 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature