Differential involvement of hippocampal subfields in the relationship between Alzheimer's pathology and memory interference in older adults.

ABSTRACT:

Introduction

We tested whether Alzheimer's disease (AD) pathology predicts memory deficits in non-demented older adults through its effects on medial temporal lobe (MTL) subregional volume.

Methods

Thirty-two, non-demented older adults with cerebrospinal fluid (CSF) (amyloid-beta [Aβ]₄₂/Aβ₄₀, phosphorylated tau [p-tau]₁₈₁, total tau [t-tau]), positron emission tomography (PET; 18F-florbetapir), high-resolution structural magnetic resonance imaging (MRI), and neuropsychological assessment were analyzed. We examined relationships between biomarkers and a highly granular measure of memory consolidation, retroactive interference (RI).

Results

Biomarkers of AD pathology were related to RI. Dentate gyrus (DG) and CA3 volume were uniquely ass

SUBMITTER: Adams JN 

PROVIDER: S-EPMC10075195 | biostudies-literature | 2023 Apr-Jun

REPOSITORIES: biostudies-literature