Amitriptyline's anticholinergic adverse drug reactions-A systematic multiple-indication review and meta-analysis.

ABSTRACT:

Background

Half the US population uses drugs with anticholinergic properties. Their potential harms may outweigh their benefits. Amitriptyline is among the most frequently prescribed anticholinergic medicinal products, is used for multiple indications, and rated as strongly anticholinergic. Our objective was to explore and quantify (anticholinergic) adverse drug reactions (ADRs) in patients taking amitriptyline vs. placebo in randomized controlled trials (RCTs) involving adults and healthy individuals.

Methods

We searched electronic databases from their inception until 09/2022, and clinical trial registries from their inception until 09/2022. We also performed manual reference searches. Two independent reviewers selected RCTs with ≥100 participants of ≥18 years, that compare

SUBMITTER: Brueckle MS 

PROVIDER: S-EPMC10075391 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature