X-chromosome target specificity diverged between dosage compensation mechanisms of two closely related Caenorhabditis species.

ABSTRACT: An evolutionary perspective enhances our understanding of biological mechanisms. Comparison of sex determination and X-chromosome dosage compensation mechanisms between the closely related nematode species Caenorhabditis briggsae (Cbr) and Caenorhabditis elegans (Cel) revealed that the genetic regulatory hierarchy controlling both processes is conserved, but the X-chromosome target specificity and mode of binding for the specialized condensin dosage compensation complex (DCC) controlling X expression have diverged. We identified two motifs within Cbr DCC recruitment sites that are highly enriched on X: 13 bp MEX and 30 bp MEX II. Mutating either MEX or MEX II in an endogenous recruitment site with multiple copies of one or both motifs reduced binding, but

SUBMITTER: Yang Q 

PROVIDER: S-EPMC10076027 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature