Early-Life Gut Microbiota Governs Susceptibility to Colitis via Microbial-Derived Ether Lipids.

ABSTRACT: Localized intestine inflammation could induce short-term increases in colonic oxygenation and leads to increases in the aerobic bacteria population and reduction in the anaerobic bacteria population by changing the intestinal environment. However, the mechanisms involved and the associated functions of intestinal anaerobes in gut health still remain unclear. Here, we found that early-life depletion of gut microbiota exacerbated later colitis, while mid-life microbiota depletion showed partially reduced colitis. Notably, we observed that early-life gut microbiota depletion confers susceptibility to ferroptosis in colitis. In contrast, restitution of early-life microbiota conferred protection against colitis and inhibited ferroptosis triggered by gut microbiota dysbiosis. Similarly, coloniza

SUBMITTER: Liu Y 

PROVIDER: S-EPMC10076029 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature