From primordial clocks to circadian oscillators.

ABSTRACT: Circadian rhythms play an essential part in many biological processes, and only three prokaryotic proteins are required to constitute a true post-translational circadian oscillator¹. The evolutionary history of the three Kai proteins indicates that KaiC is the oldest member and a central component of the clock². Subsequent additions of KaiB and KaiA regulate the phosphorylation state of KaiC for time synchronization. The canonical KaiABC system in cyanobacteria is well understood^3-6, but little is known about more ancient systems that only possess KaiBC. However, there are reports that they might exhibit a basic, hourglass-like timekeeping mechanism^7-9. Here we investigate the primordial circadian clock in Rhodobacter sphaeroides, which contains

SUBMITTER: Pitsawong W 

PROVIDER: S-EPMC10076222 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature