Predicting recombination suppression outside chromosomal inversions in Drosophila melanogaster using crossover interference theory.

ABSTRACT: Recombination suppression in chromosomal inversion heterozygotes is a well-known but poorly understood phenomenon. Surprisingly, recombination suppression extends far outside of inverted regions where there are no intrinsic barriers to normal chromosome pairing, synapsis, double-strand break formation, or recovery of crossover products. The interference hypothesis of recombination suppression proposes heterozygous inversion breakpoints possess chiasma-like properties such that recombination suppression extends from these breakpoints in a process analogous to crossover interference. This hypothesis is qualitatively consistent with chromosome-wide patterns of recombination suppression extending to both inverted and uninverted regions of the chromosome. The present study generated quantitativ

SUBMITTER: Koury SA 

PROVIDER: S-EPMC10076299 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature