Fetal exposure to valproic acid dysregulates the expression of autism-linked genes in the developing cerebellum.

ABSTRACT: Autism spectrum disorder (ASD) includes a set of highly heritable neurodevelopmental syndromes characterized by social and communication impairment, repetitive behaviour, and intellectual disability. Although mutations in multiple genes have been associated to ASD, most patients lack detectable genetic alterations. For this reason, environmental factors are commonly thought to also contribute to ASD aetiology. Transcriptome analyses have revealed that autistic brains possess distinct gene expression signatures, whose elucidation can provide insights about the mechanisms underlying the effects of ASD-causing genetic and environmental factors. Herein, we have identified a coordinated and temporally regulated programme of gene expression in the post-natal development of cerebellum, a brain ar

SUBMITTER: Guerra M 

PROVIDER: S-EPMC10076313 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature