The effects of reserpine on depression: A systematic review.

ABSTRACT:

Background

Reserpine is an effective antihypertensive drug, but its role in routine practice has declined such that it is rarely used. This is largely based on the assumption that reserpine causes depression. This assumption was a foundation for the original monoamine hypothesis of depression. However, there remains conflicting evidence as to whether reserpine causes depression, and no systematic review of available evidence.

Aims

We systematically reviewed evidence on effects of reserpine on depressive and related symptoms (e.g. anxiety, suicidal ideation).

Method

Electronic searches of MEDLINE, Embase and PsycINFO were conducted to identify studies up to 14 February 2021. Studies of any methodological design involving reserpine-treated and reserpine-untreated condit

SUBMITTER: Strawbridge R 

PROVIDER: S-EPMC10076328 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature