Changes in insulin resistance following antidepressant treatment mediate response in major depressive disorder.

ABSTRACT:

Background

Insulin resistance (IR) is a potential predictor of antidepressant treatment response.

Aims

We assess changes in IR after antidepressant treatment and whether these changes have any effect on treatment response. Also, to see whether changes in IR mediates relationship between C-reactive protein (CRP) and antidepressant efficacy.

Methods

This is a secondary analysis of an 8-week, open-label clinical trial with 95 adults experiencing a major depressive episode. Response to vortioxetine was measured using the Montgomery-Åsberg Depression Rating Scale (MADRS). Generalized estimating equation models were utilized for this intent-to-treat analysis.

Results

When adjusted for age, sex, and body mass index, there was a significant increase in IR following tre

SUBMITTER: Rashidian H 

PROVIDER: S-EPMC10076336 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature