Systematic review and meta-analysis of augmentation and combination treatments for early-stage treatment-resistant depression.

ABSTRACT:

Background

Major depressive disorder (MDD) is a highly burdensome health condition, for which there are numerous accepted pharmacological and psychological interventions. Adjunctive treatment (augmentation/combination) is recommended for the ~50% of MDD patients who do not adequately respond to first-line treatment. We aimed to evaluate the current evidence for concomitant approaches for people with early-stage treatment-resistant depression (TRD; defined below).

Methods

We systematically searched Medline and Institute for Scientific Information Web of Science to identify randomised controlled trials of adjunctive treatment of ⩾10 adults with MDD who had not responded to ⩾1 adequate antidepressant. The cochrane risk of bias (RoB) tool was used to assess study quality. Pre-po

SUBMITTER: Scott F 

PROVIDER: S-EPMC10076341 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature