Selection, recombination and population history effects on runs of homozygosity (ROH) in wild red deer (Cervus elaphus).

ABSTRACT: The distribution of runs of homozygosity (ROH) may be shaped by a number of interacting processes such as selection, recombination and population history, but little is known about the importance of these mechanisms in shaping ROH in wild populations. We combined an empirical dataset of >3000 red deer genotyped at >35,000 genome-wide autosomal SNPs and evolutionary simulations to investigate the influence of each of these factors on ROH. We assessed ROH in a focal and comparison population to investigate the effect of population history. We investigated the role of recombination using both a physical map and a genetic linkage map to search for ROH. We found differences in ROH distribution between both populations and map types indicating that population history and local recombination rate

SUBMITTER: Hewett AM 

PROVIDER: S-EPMC10076382 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature