Ontology highlight
ABSTRACT:
SUBMITTER: Kotsaris G
PROVIDER: S-EPMC10076435 | biostudies-literature | 2023 Apr
REPOSITORIES: biostudies-literature
Kotsaris Georgios G Qazi Taimoor H TH Bucher Christian H CH Zahid Hafsa H Pöhle-Kronawitter Sophie S Ugorets Vladimir V Jarassier William W Börno Stefan S Timmermann Bernd B Giesecke-Thiel Claudia C Economides Aris N AN Le Grand Fabien F Vallecillo-García Pedro P Knaus Petra P Geissler Sven S Stricker Sigmar S
NPJ Regenerative medicine 20230405 1
Skeletal muscle regeneration requires the coordinated interplay of diverse tissue-resident- and infiltrating cells. Fibro-adipogenic progenitors (FAPs) are an interstitial cell population that provides a beneficial microenvironment for muscle stem cells (MuSCs) during muscle regeneration. Here we show that the transcription factor Osr1 is essential for FAPs to communicate with MuSCs and infiltrating macrophages, thus coordinating muscle regeneration. Conditional inactivation of Osr1 impaired mus ...[more]