Dynamic causal modelling of auditory surprise during disconnected consciousness: The role of feedback connectivity.

ABSTRACT: The neural mechanisms through which individuals lose sensory awareness of their environment during anesthesia remains poorly understood despite being of vital importance to the field. Prior research has not distinguished between sensory awareness of the environment (connectedness) and consciousness itself. In the current study, we investigated the neural correlates of sensory awareness by contrasting neural responses to an auditory roving oddball paradigm during consciousness with sensory awareness (connected consciousness) and consciousness without sensory awareness (disconnected consciousness). These states were captured using a serial awakening paradigm with the sedative alpha2 adrenergic agonist dexmedetomidine, chosen based on our published hypothesis that suppression of noradrenaline

SUBMITTER: Casey CP 

PROVIDER: S-EPMC10076444 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature