Four new lanostane triterpenoids featuring extended π-conjugated systems from the stems of Kadsura coccinea.

ABSTRACT: Four new 14(13 → 12)-abeolanostane triterpenoids featuring extended π-conjugated systems, kadcoccitanes E-H (1-4), were obtained from the stems of Kadsura coccinea through using a HPLC - UV-guided approach. Their structural and configurational determination was accomplished through extensive spectroscopic analysis coupled with quantum chemical calculations. Kadcoccitanes E-H were tested for their cytotoxic activities against five human tumor cell lines (HL-60, A-549, SMMC-7721, MDA-MB-231, SW-480) but none of them exhibited activities at the concentration 40 μM.

SUBMITTER: Zhang QQ 

PROVIDER: S-EPMC10076471 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature