Identification of anoikis-related genes classification patterns and immune infiltration characterization in ischemic stroke based on machine learning.

ABSTRACT:

Introduction

Ischemic stroke (IS) is a type of stroke that leads to high mortality and disability. Anoikis is a form of programmed cell death. When cells detach from the correct extracellular matrix, anoikis disrupts integrin junctions, thus preventing abnormal proliferating cells from growing or attaching to an inappropriate matrix. Although there is growing evidence that anoikis regulates the immune response, which makes a great contribution to the development of IS, the role of anoikis in the pathogenesis of IS is rarely explored.

Methods

First, we downloaded GSE58294 set and GSE16561 set from the NCBI GEO database. And 35 anoikis-related genes (ARGs) were obtained from GSEA website. The CIBERSORT algorithm was used to estimate the relative proportions of 22 infiltrating

SUBMITTER: Qin X 

PROVIDER: S-EPMC10076550 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature