Dried fruit intake causally protects against low back pain: A Mendelian randomization study.

ABSTRACT:

Background

Low back pain is the leading cause of years lived with disability worldwide. The aim of this study was to evaluate whether dried fruit intake causally protects against low back pain using two-sample Mendelian randomization (MR).

Methods

We obtained summary-level data for dried fruit intake (N = 421,764) from the IEU Open GWAS Project. Forty-one independent genetic variants proxied dried fruit intake. The corresponding data for low back pain were derived from the FinnGen project (13,178 cases and 164,682 controls; discovery data) and the Neale lab (5,423 cases and 355,771 controls; replication data). We conducted univariable and multivariable MR analyses.

Results

In the univariable MR analysis, the inverse variance weighted estimate showed that greate

SUBMITTER: Huang J 

PROVIDER: S-EPMC10076586 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature