Monoacylglycerol lipase regulates macrophage polarization and cancer progression in uveal melanoma and pan-cancer.

ABSTRACT:

Background

Although lipid metabolism has been proven to play a key role in the development of cancer, its significance in uveal melanoma (UM) has not yet been elucidated in the available literature.

Methods

To identify the expression patterns of lipid metabolism in 80 UM patients from the TCGA database, 47 genes involved in lipid metabolism were analyzed. Consensus clustering revealed two distinct molecular groups. ESTIMATE, TIMER, and ssGSEA analyses were done to identify the differences between the two subgroups in tumor microenvironment (TME) and immune state. Using Cox regression and Lasso regression analysis, a risk model based on differentially expressed genes (DEGs) was developed. To validate the expression of monoacylglycerol lipase (MGLL) and immune infiltration in

SUBMITTER: Tan Y 

PROVIDER: S-EPMC10076602 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature