Genomic analysis of chromosomal cointegrated bla _NDM-1-carrying ICE and bla _RSA-1-carrying IME from clinical multidrug resistant Aeromonas caviae.

ABSTRACT:

Introduction

The objective of this study is to thoroughly analyze the detailed genomic characteristics of clinical strain 211703 of Aeromonas caviae, which co-carrying bla _RSA-1 and bla _NDM-1 genes. 211703 was isolated from the patient's cerebrospinal fluid drainage sample in a Chinese tertiary hospital.

Methods

Carbapenemase NDM was detected by the immunocolloidal gold technique. The MIC values were determined by VITEK2. The whole genome sequence of 211703 was analyzed using phylogenetics, genomic comparison, and extensive dissection.

Results

This study revealed that 211703 only contained a single 4.78 Mb chromosome (61.8% GC content), and no plasmids were discovered in 211703. 15 different types of resistant genes were dete

SUBMITTER: Luo X 

PROVIDER: S-EPMC10076717 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature