Maternal immunization with pneumococcal surface protein A provides the immune memories of offspring against pneumococcal infection.

ABSTRACT:

Introduction

Streptococcus pneumoniae (S. pneumoniae) is one of the most widespread pathogens in the world and one of the largest infectious causes of infant mortality. Although current vaccines have various benefits, antibiotic resistance and the inability to vaccinate infants less than one year old demands the development of new protective strategies. One strategy, 'maternal immunization', is to protect infants by passive immunity from an immunized mother, although its mechanism is still not fully understood.

Materials and methods

The current study aimed to acquire immunity against S. pneumoniae in infants by maternal immunization with pneumococcal common antigen, pneumococcal surface protein A (PspA). Four-week-old female mice were immunized with reco

SUBMITTER: Kono M 

PROVIDER: S-EPMC10076723 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature