Transient increase in atherosclerotic plaque macrophage content following <i>Streptococcus pneumoniae</i> pneumonia in ApoE-deficient mice.

ABSTRACT:

Introduction

Despite epidemiological associations between community acquired pneumonia (CAP) and myocardial infarction, mechanisms that modify cardiovascular disease during CAP are not well defined. In particular, largely due to a lack of relevant experimental models, the effect of pneumonia on atherosclerotic plaques is unclear. We describe the development of a murine model of the commonest cause of CAP, Streptococcus pneumoniae pneumonia, on a background of established atherosclerosis. We go on to use our model to investigate the effects of pneumococcal pneumonia on atherosclerosis.

Methods

C57BL/6J and ApoE^-/- mice were fed a high fat diet to promote atherosclerotic plaque formation. Mice were then infected with a range of S. pneumoniae serotypes

SUBMITTER: Bazaz R 

PROVIDER: S-EPMC10076735 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature