Genetic deletion of HVEM in a leukemia B cell line promotes a preferential increase of PD-1^- stem cell-like T cells over PD-1⁺ T cells curbing tumor progression.

ABSTRACT:

Introduction

A high frequency of mutations affecting the gene encoding Herpes Virus Entry Mediator (HVEM, TNFRSF14) is a common clinical finding in a wide variety of human tumors, including those of hematological origin.

Methods

We have addressed how HVEM expression on A20 leukemia cells influences tumor survival and its involvement in the modulation of the anti-tumor immune responses in a parental into F1 mouse tumor model of hybrid resistance by knocking-out HVEM expression. HVEM WT or HVEM KO leukemia cells were then injected intravenously into semiallogeneic F1 recipients and the extent of tumor dissemination was evaluated.

Results

The loss of HVEM expression on A20 leukemia cells led to a significant increase of lymphoid and myeloid tumor cell infiltration curbin

SUBMITTER: Del Rio ML 

PROVIDER: S-EPMC10076739 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature