Microvascular and macrovascular complications of type 2 diabetes mellitus: Exome wide association analyses.

ABSTRACT:

Background

Type 2 diabetes mellitus (T2DM) is a chronic, metabolic disorder in which concomitant insulin resistance and β-cell impairment lead to hyperglycemia, influenced by genetic and environmental factors. T2DM is associated with long-term complications that have contributed to the burden of morbidity and mortality worldwide. The objective of this manuscript is to conduct an Exome-Wide Association Study (EWAS) on T2DM Emirati individuals to improve our understanding on diabetes-related complications to improve early diagnostic methods and treatment strategies.

Methods

This cross-sectional study recruited 310 Emirati participants that were stratified according to their medically diagnosed diabetes-related complications: diabetic retinopathy, diabetic neuropathy, diabetic

SUBMITTER: Mansour A 

PROVIDER: S-EPMC10076756 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature