Exploring the potential targets of the Abrus cantoniensis Hance in the treatment of hepatitis E based on network pharmacology.

ABSTRACT: Hepatitis E is a disease of public health significance caused by the cross-species transmission of zoonotic hepatitis E virus (HEV) infection. There are no specific drugs. In this study, network pharmacology was used to reveal the mechanism of treatment of the active constituents of the Abrus cantoniensis Hance on hepatitis E. Based on the previously published representative components of A. cantoniensis Hance, we were screened the active components with OB ≥ 20% and DL ≥ 0.1 in A. cantoniensis Hance based on the TCMSP, predicted the target online through Swiss target prediction, and integrated the hepatitis E target in the GeneCards and DisGenet databases. Then, the core target was screened and the GO and KEGG enrichment and the network of the drug-active-ingredient-d

SUBMITTER: Xu Z 

PROVIDER: S-EPMC10076809 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature