African Spiny Mice (Acomys) Exhibit Mild Osteoarthritis Following Meniscal Injury.

ABSTRACT:

Objective

Hyaline cartilage has limited innate healing abilities and hyaline cartilage loss is a hallmark of osteoarthritis (OA). Animal models can provide important insights into cartilage regeneration potential. One such animal model, the African spiny mouse (Acomys), is capable of regenerating skin, skeletal muscle, and elastic cartilage. This study aims to evaluate whether these regenerative abilities protect Acomys with meniscal injury from OA-related joint damage and behaviors indicative of joint pain and dysfunction.

Design

Acomys received destabilization of the medial meniscus (DMM) surgery (n = 11) or a skin incision (n = 10). Gait testing occurred at 4, 6, 8, 10, and 12 weeks after surgery. At endpoint, joints were processed for h

SUBMITTER: Chan KM 

PROVIDER: S-EPMC10076895 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature