Sex hormones in the risk of breast cancer: a two-sample Mendelian randomization study.

ABSTRACT: Multiple evidence has suggested the essential role of sex hormones in the susceptibility of breast cancer. However, whether there exists a causal association and the effect direction remains controversial. To examine the causative role of hormones in the risk of breast cancer, we first estimated their genetic correlation, and then conducted two-sample and multivariable Mendelian randomization analyses using summary statistics from genome-wide association studies of major sex hormones including testosterone (N=230,454), estradiol (N=163,985) and progesterone (N=1,261), together with breast cancer (N=228,951). We further performed subtype analysis focusing on estrogen receptor (ER)+ breast cancer (N=175,475) and ER- breast cancer (N=127,442), and conducted extensive sensitivity analyses. We

SUBMITTER: Ke B 

PROVIDER: S-EPMC10077051 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature