TRF-20-M0NK5Y93-induced MALAT1 promotes colon cancer metastasis through alternative splicing of SMC1A.

ABSTRACT: Recent studies have indicated that changes in the tumor microenvironment, such as hypoxia, result in the discrepant expression of noncoding small RNA tRNA-derived fragments (tRFs), affecting the phenotype of tumor metastasis. The biological function of tRFs in tumors has attracted increasing attention, but the mechanism by which tRFs mediate tumor metastasis has not been clarified. The direct regulatory relationship between tRFs and lncRNAs and the mechanism by which noncoding RNAs regulate alternative splicing are still unknown. In this study, the mechanism of tRF-mediated SMC1A alternative splicing and regulation of colon cancer metastasis was studied from multiple dimensions of cell, molecule, animal and clinical. Our present studies revealed that tRF-20-M0NK5Y93 inhibits colon cancer m

SUBMITTER: Luan N 

PROVIDER: S-EPMC10077053 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature