Global-feature of autoimmune glomerulonephritis using proteomic analysis of laser capture microdissected glomeruli.

ABSTRACT:

Background

IgA nephropathy (IgAN), (LN), membranous nephropathy (MN), and minimal change nephropathy (MCN) are all belonged to autoimmune glomerulonephritis. This study aimed to identify the specific proteomic characteristics of the four GNs diseases in order to provide frameworks for developing the appropriate drug for patients diagnosed with GNs disease.

Methods

Liquid chromatography-tandem mass spectrometry (LC-MS/MS) was utilized to investigate proteomic features of glomerular tissues obtained by laser capture microdissection (LCM). 8 normal control cases, 11 IgAN cases, 19 LN cases, 5 MN cases, and 3 MCN cases in this study were selected for bioinformatics analyses.

Results

The shared overlapping proteins among the top 100 DEPs of each GNs type were mostly downre

SUBMITTER: Dong J 

PROVIDER: S-EPMC10077062 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature