Obsessive-Compulsive Disorder and Its Cross-Generational Familial Association With Anxiety Disorders in a National Swedish Extended Adoption Study.

ABSTRACT:

Importance

We know little about the transmission of obsessive-compulsive disorder (OCD) across generations.

Objective

To evaluate the sources of parent-offspring transmission of OCD and familial cross-generational association with more typical anxiety disorders.

Design, setting, and participants

This Swedish population register-based study analyzed data for offspring born in Sweden from 1960 to 1995 from the following 4 family types: intact, not-lived-with biological father, lived-with stepfather, and adoptive. Follow-up occurred on December 31, 2018, and data were analyzed from April 6, 2022, to September 26, 2022.

Exposures

Three sources of parent-offspring resemblance: genes plus rearing, genes only, and rearing only.

Main outcomes and measures

Diagno

SUBMITTER: Kendler KS 

PROVIDER: S-EPMC10077103 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature