Association of Primary Immunodeficiencies in Parents With Psychiatric Disorders and Suicidal Behavior in Their Offspring.

ABSTRACT:

Importance

Maternal immune activation (MIA) leading to altered neurodevelopment in utero is a hypothesized risk factor for psychiatric outcomes in offspring. Primary antibody immunodeficiencies (PIDs) constitute a unique natural experiment to test the MIA hypothesis of mental disorders.

Objective

To assess the association of maternal and paternal PIDs with psychiatric disorders and suicidal behavior in offspring.

Design, setting, and participants

Cohort study of 4 294 169 offspring of parents with and without PIDs living in Sweden at any time between 1973 and 2013. Data were extracted from Swedish nationwide health and administrative registers and were analyzed from May 5 to September 30, 2022. All individuals with diagnoses of PIDs identified between 1973 and 2013 fr

SUBMITTER: Isung J 

PROVIDER: S-EPMC10077106 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature